{"id":9734,"date":"2025-04-23T20:11:14","date_gmt":"2025-04-23T23:11:14","guid":{"rendered":"https:\/\/gastropedia.pub\/pt\/?p=9734"},"modified":"2025-04-01T21:04:42","modified_gmt":"2025-04-02T00:04:42","slug":"procineticos-mecanismo-de-acao-indicacoes-e-seguranca","status":"publish","type":"post","link":"https:\/\/gastropedia.pub\/pt\/gastroenterologia\/procineticos-mecanismo-de-acao-indicacoes-e-seguranca\/","title":{"rendered":"Procin\u00e9ticos: Mecanismo de A\u00e7\u00e3o, Indica\u00e7\u00f5es e Seguran\u00e7a"},"content":{"rendered":"<div class=\"pdfprnt-buttons pdfprnt-buttons-post pdfprnt-top-right\"><a href=\"https:\/\/gastropedia.pub\/pt\/wp-json\/wp\/v2\/posts\/9734?print=pdf\" class=\"pdfprnt-button pdfprnt-button-pdf\" target=\"_blank\" ><img decoding=\"async\" src=\"https:\/\/gastropedia.pub\/pt\/wp-content\/plugins\/pdf-print\/images\/pdf.png\" alt=\"image_pdf\" title=\"Ver PDF\" \/><\/a><a href=\"https:\/\/gastropedia.pub\/pt\/wp-json\/wp\/v2\/posts\/9734?print=print\" class=\"pdfprnt-button pdfprnt-button-print\" target=\"_blank\" ><img decoding=\"async\" src=\"https:\/\/gastropedia.pub\/pt\/wp-content\/plugins\/pdf-print\/images\/print.png\" alt=\"image_print\" title=\"Conte\u00fado de impress\u00e3o\" \/><\/a><\/div>\n<p>Os procin\u00e9ticos s\u00e3o uma classe de f\u00e1rmacos utilizados no manejo de dist\u00farbios da motilidade gastrointestinal. Seu mecanismo de a\u00e7\u00e3o baseia-se na estimula\u00e7\u00e3o das contra\u00e7\u00f5es do trato digestivo, favorecendo o esvaziamento g\u00e1strico e o tr\u00e2nsito intestinal. No Brasil, os principais representantes dessa classe incluem metoclopramida, domperidona, bromoprida, prucaloprida, neostigmina e eritromicina. <\/p>\n\n\n\n<p>Este post resume o <em><strong>Expert Review da European Society of Neurogastroenterology and Motility em conjunto com The American Neurogastroenterology and Motility Society<\/strong><\/em>, que explora suas caracter\u00edsticas farmacol\u00f3gicas, indica\u00e7\u00f5es cl\u00ednicas e seguran\u00e7a.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-\"> <\/h2>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-1-metoclopramida\"><strong>1. Metoclopramida<\/strong><\/h2>\n\n\n\n<p>A metoclopramida atua como antagonista dos receptores dopamin\u00e9rgicos D2 e agonista parcial dos receptores serotonin\u00e9rgicos 5-HT4, aumentando a libera\u00e7\u00e3o de acetilcolina no trato gastrointestinal. Esse mecanismo resulta no aumento da motilidade esof\u00e1gica e g\u00e1strica.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-indicacoes\"><br><strong>Indica\u00e7\u00f5es:<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Gastroparesia diab\u00e9tica;<\/li>\n\n\n\n<li>Doen\u00e7a do refluxo gastroesof\u00e1gico (DRGE);<\/li>\n\n\n\n<li>N\u00e1useas e v\u00f4mitos associados a cirurgias ou quimioterapia.<\/li>\n<\/ul>\n\n\n\n<p><strong>Efeitos adversos:<\/strong> O uso prolongado da metoclopramida est\u00e1 associado a um risco aumentado de efeitos adversos neurol\u00f3gicos, incluindo discinesia tardia irrevers\u00edvel, parkinsonismo, acatisia e distonia aguda. Esses efeitos extrapiramidais ocorrem devido \u00e0 sua capacidade de atravessar a barreira hematoencef\u00e1lica e antagonizar os receptores dopamin\u00e9rgicos centrais. Al\u00e9m disso, pode causar seda\u00e7\u00e3o e sintomas auton\u00f4micos, como hipotens\u00e3o ortost\u00e1tica. Devido a esses riscos, recomenda-se que seu uso cont\u00ednuo n\u00e3o ultrapasse 12 semanas, conforme diretrizes da FDA.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-\"> <\/h2>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-2-domperidona\"><strong>2. Domperidona<\/strong><\/h2>\n\n\n\n<p>A domperidona \u00e9 um antagonista D2 que, ao contr\u00e1rio da metoclopramida, n\u00e3o atravessa a barreira hematoencef\u00e1lica, reduzindo os riscos de efeitos extrapiramidais.<br><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-indicacoes-0\"><strong>Indica\u00e7\u00f5es:<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Dispepsia funcional;<\/li>\n\n\n\n<li>DRGE;<\/li>\n\n\n\n<li>Gastroparesia leve a moderada.<\/li>\n<\/ul>\n\n\n\n<p><strong>Efeitos adversos:<\/strong> A domperidona pode prolongar o intervalo QT e aumentar o risco de arritmias ventriculares, especialmente em pacientes idosos ou com doen\u00e7as cardiovasculares preexistentes. O risco cardiovascular \u00e9 dose-dependente e pode ser agravado pelo uso concomitante de outros f\u00e1rmacos que prolongam o intervalo QT, como alguns antibi\u00f3ticos macrol\u00eddeos e antidepressivos tric\u00edclicos. Recomenda-se monitoramento cuidadoso em pacientes de alto risco.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-3-bromoprida\"><br><strong>3. Bromoprida<\/strong><\/h2>\n\n\n\n<p>A bromoprida compartilha o mesmo mecanismo de a\u00e7\u00e3o da metoclopramida, sendo um antagonista D2 com propriedades serotonin\u00e9rgicas moderadas.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-indicacoes-1\"><strong>Indica\u00e7\u00f5es:<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>N\u00e1useas e v\u00f4mitos de diversas etiologias;<\/li>\n\n\n\n<li>Gastroparesia leve;<\/li>\n\n\n\n<li>DRGE.<\/li>\n<\/ul>\n\n\n\n<p><strong>Efeitos adversos:<\/strong> Entre os efeitos colaterais mais comuns est\u00e3o sintomas extrapiramidais, seda\u00e7\u00e3o e fadiga, o que pode limitar seu uso cr\u00f4nico.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-4-prucaloprida\"><br><strong>4. Prucaloprida<\/strong><\/h2>\n\n\n\n<p>A prucaloprida \u00e9 um agonista altamente seletivo dos receptores 5-HT4, estimulando a libera\u00e7\u00e3o de acetilcolina no trato gastrointestinal e promovendo um aumento na motilidade intestinal, com maior impacto na motilidade col\u00f4nica.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-indicacoes-2\"><strong>Indica\u00e7\u00f5es:<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Constipa\u00e7\u00e3o cr\u00f4nica idiop\u00e1tica resistente ao tratamento com laxantes.<\/li>\n<\/ul>\n\n\n\n<p><strong>Efeitos adversos:<\/strong> Pode causar cefaleia, diarreia e dor abdominal. Seu perfil de seguran\u00e7a cardiovascular \u00e9 favor\u00e1vel, sem associa\u00e7\u00e3o relevante com prolongamento do intervalo QT.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-5-neostigmina\"><br><strong>5. Neostigmina<\/strong><\/h2>\n\n\n\n<p>A neostigmina \u00e9 um inibidor da acetilcolinesterase, aumentando os n\u00edveis de acetilcolina na jun\u00e7\u00e3o neuromuscular e promovendo contra\u00e7\u00f5es no trato gastrointestinal.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-indicacoes-3\"><strong>Indica\u00e7\u00f5es:<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Pseudo-obstru\u00e7\u00e3o col\u00f4nica aguda (s\u00edndrome de Ogilvie);<\/li>\n\n\n\n<li>Dist\u00farbios de motilidade intestinal p\u00f3s-operat\u00f3rios.<\/li>\n<\/ul>\n\n\n\n<p><strong>Efeitos adversos:<\/strong> Os efeitos colaterais incluem bradicardia, c\u00f3licas abdominais, sudorese excessiva e hipersaliva\u00e7\u00e3o. O monitoramento card\u00edaco \u00e9 recomendado durante sua administra\u00e7\u00e3o.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-6-eritromicina\"><br><strong>6. Eritromicina<\/strong><\/h2>\n\n\n\n<p>Al\u00e9m de sua fun\u00e7\u00e3o antibi\u00f3tica, a eritromicina atua como um agonista dos receptores de motilina, estimulando contra\u00e7\u00f5es g\u00e1stricas semelhantes \u00e0s do complexo motor migrat\u00f3rio.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-indicacoes-4\"><strong>Indica\u00e7\u00f5es:<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Gastroparesia grave, especialmente em pacientes diab\u00e9ticos;<\/li>\n\n\n\n<li>Esvaziamento g\u00e1strico antes de procedimentos endosc\u00f3picos;<\/li>\n\n\n\n<li>Pseudo-obstru\u00e7\u00e3o intestinal.<\/li>\n<\/ul>\n\n\n\n<p><strong>Efeitos adversos:<\/strong> Seu uso prolongado pode induzir taquifilaxia, al\u00e9m de interferir na microbiota intestinal e aumentar o risco de resist\u00eancia bacteriana. Tamb\u00e9m est\u00e1 associada a prolongamento do intervalo QT em alguns pacientes.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-doses-recomendadas\"><br><strong>Doses recomendadas:<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><div class=\"pcrstb-wrap\"><table class=\"has-very-light-gray-to-cyan-bluish-gray-gradient-background has-background has-fixed-layout\"><tbody><tr><td>Metoclopramida: 10 mg via oral, intramuscular ou intravenosa, at\u00e9 3 vezes ao dia (m\u00e1ximo de 30 mg\/dia).<br><br>Domperidona: 10 mg via oral, at\u00e9 3 vezes ao dia (m\u00e1ximo de 30 mg\/dia).<br><br>Bromoprida: 10 mg via oral ou intramuscular, at\u00e9 3 vezes ao dia (m\u00e1ximo de 30 mg\/dia).<br><br>Prucaloprida: 2 mg via oral, uma vez ao dia (1 mg para idosos ou pacientes com insufici\u00eancia renal grave).<br><br>Neostigmina: 0,5\u20132 mg intravenoso, administrado lentamente (monitoramento card\u00edaco recomendado devido ao risco de bradicardia).<br><br>Eritromicina: 250\u2013500 mg via oral, a cada 8 horas; ou 3 mg\/kg intravenoso a cada 8 horas em casos de gastroparesia severa.<\/td><\/tr><\/tbody><\/table><\/div><\/figure>\n\n\n\n<p><br><br><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/gastropedia.pub\/pt\/wp-content\/uploads\/2025\/03\/FIGURA1.jpg\" data-rel=\"penci-gallery-image-content\" ><img fetchpriority=\"high\" decoding=\"async\" width=\"946\" height=\"1024\" src=\"https:\/\/gastropedia.pub\/pt\/wp-content\/uploads\/2025\/03\/FIGURA1-946x1024.jpg\" alt=\"\" class=\"wp-image-9735\" srcset=\"https:\/\/gastropedia.pub\/pt\/wp-content\/uploads\/2025\/03\/FIGURA1-946x1024.jpg?v=1742332923 946w, https:\/\/gastropedia.pub\/pt\/wp-content\/uploads\/2025\/03\/FIGURA1-277x300.jpg?v=1742332923 277w, https:\/\/gastropedia.pub\/pt\/wp-content\/uploads\/2025\/03\/FIGURA1-768x832.jpg?v=1742332923 768w, https:\/\/gastropedia.pub\/pt\/wp-content\/uploads\/2025\/03\/FIGURA1-585x634.jpg?v=1742332923 585w, https:\/\/gastropedia.pub\/pt\/wp-content\/uploads\/2025\/03\/FIGURA1.jpg?v=1742332923 1170w\" sizes=\"(max-width: 946px) 100vw, 946px\" \/><\/a><figcaption class=\"wp-element-caption\"><br>Figura 1: Procin\u00e9ticos e seus mecanismos de a\u00e7\u00e3o.<br>Ref: Bor S, et al. Neurogastroenterol Motil. 2024.<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-consideracoes-finais\"><br><strong>Considera\u00e7\u00f5es Finais<\/strong><\/h2>\n\n\n\n<p class=\"has-very-light-gray-to-cyan-bluish-gray-gradient-background has-background\">Os procin\u00e9ticos t\u00eam um papel fundamental no tratamento de dist\u00farbios da motilidade gastrointestinal, mas seu uso deve ser individualizado conforme o perfil cl\u00ednico do paciente. Enquanto a metoclopramida, domperidona e bromoprida s\u00e3o indicadas para gastroparesia e DRGE, a prucaloprida \u00e9 uma op\u00e7\u00e3o mais segura para constipa\u00e7\u00e3o cr\u00f4nica idiop\u00e1tica. A neostigmina e a eritromicina s\u00e3o reservadas para casos graves, como pseudo-obstru\u00e7\u00e3o intestinal e gastroparesia severa. A decis\u00e3o terap\u00eautica deve equilibrar efic\u00e1cia e seguran\u00e7a, evitando o uso prolongado quando poss\u00edvel.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-referencias\"><br><strong>Refer\u00eancias<\/strong><\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Bor S, Kalkan \u0130H, Savarino E, Rao S, Tack J, Pasricha J, Cangemi D, Schol J, Karunaratne T, Ghisa M, Ahuja NK, Lacy B. Prokinetics-safety and efficacy: The European Society of Neurogastroenterology and Motility\/The American Neurogastroenterology and Motility Society expert review.<br>Neurogastroenterol Motil. 2024 May;36(5):e14774. doi: 10.1111\/nmo.14774. Epub 2024 Mar 10. PMID: 38462678.<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-como-citar-este-artigo\"><strong>Como citar este artigo<\/strong><\/h2>\n\n\n\n<p class=\"has-very-light-gray-to-cyan-bluish-gray-gradient-background has-background\">Martins BC. Procin\u00e9ticos: Mecanismo de A\u00e7\u00e3o, Indica\u00e7\u00f5es e Seguran\u00e7a Gastropedia 2025; Vol 1. Dispon\u00edvel em: <a href=\"https:\/\/gastropedia.pub\/pt\/?p=9734\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/gastropedia.pub\/pt\/gastroenterologia\/procineticos-mecanismo-de-acao-indicacoes-e-seguranca\/<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Os procin\u00e9ticos s\u00e3o uma classe de f\u00e1rmacos utilizados no manejo de dist\u00farbios da motilidade gastrointestinal. 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