{"id":8141,"date":"2022-03-19T09:52:29","date_gmt":"2022-03-19T13:52:29","guid":{"rendered":"https:\/\/gastropedia.pub\/en\/?p=8141"},"modified":"2023-12-29T13:45:34","modified_gmt":"2023-12-29T18:45:34","slug":"fecal-microbiota-transplant","status":"publish","type":[121],"link":"https:\/\/gastropedia.pub\/en\/gastroenterology\/fecal-microbiota-transplant\/","title":{"rendered":"Fecal Microbiota Transplant"},"content":{"rendered":"
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Fecal microbiota transplantation (FMT) or fecal transplant involves the infusion of feces from a healthy donor into the gastrointestinal tract of a patient who has a disease related to alteration of the intestinal flora.<\/p>\n

The first reports of FMT are from 1700 years ago when a Chinese doctor administered suspensions of human feces orally to patients with food poisoning and\/or severe diarrhea. In 2013, the first well-designed study on the success of FMT in infections by Clostridium difficile<\/a> was published in the New England Journal of Medicine and has since motivated numerous other works related to the topic.<\/p>\n

The formal indication of FMT currently is in recurrent infections by Clostridium difficile<\/u><\/strong> with a cure rate of up to 90%.<\/p>\n

There are ongoing studies of FMT in other gastrointestinal diseases (inflammatory bowel disease, irritable bowel syndrome) as well as in endocrine (obesity, metabolic syndrome), neurological (Parkinson’s, multiple sclerosis), hematological (ITP, GVHD) and psychiatric (autism) diseases.<\/p>\n

For the smooth running of the FMT, a multidisciplinary team (attending physician whether it is the clinician, gastroclinician or geriatrician, infectious disease specialist and the endoscopist) aligned and with a well-established protocol in the service is necessary.<\/p>\n

STAGES OF THE PROCEDURE<\/strong><\/h2>\n

1. CHOICE OF DONOR<\/strong><\/h3>\n

The donor can be related or not. This person will have to go through a rigorous infectious screening and a questionnaire regarding the presence of other diseases that may make donation unfeasible.<\/p>\n

2. COLLECTION, PREPARATION AND ADMINISTRATION OF MATERIAL<\/strong><\/h3>\n

The donor should arrive at the laboratory on the day of the procedure and the ideal time between the collection of feces and the infusion of the material is 6 hours. The fecal weight should be at least 50g and the total volume of the suspension is 100 to 200ml, which will be infused depending on the chosen route. There is also the option to freeze the material but it is preferable to use fresh feces (see image below).<\/p>\n

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3. ROUTE OF ADMINISTRATION<\/strong><\/h2>\n

According to the articles published so far, all 5 routes studied show similar results. In this way, FMT can be performed by:<\/p>\n